This issue of Clinics in Plastic Surgery, guest edited by Loren Schechter and Bauback Safa, is devoted to Gender Confirmation Surgery. Articles in this issue include: Multidisciplinary Care and The Standards of Care for Transgender and Gender Non-conforming Individuals; Primary Care of Transgender and Gender Non-conforming Individuals; Mental Health Evaluation for Transgender and Gender Non-conforming Individuals; Hormonal Management for Transfeminine Individuals; Hormonal Management for Transmasculine Individuals; Facial Feminization; Breast and Body Contouring for Transgender and Gender Non-conforming Individuals; Penile inversion; Intestinal Vaginoplasty; Vaginoplasty Complications; Chest Surgery for Transgender and Gender Non-conforming Individuals; Metoidioplasty; Introduction to Phalloplasty; Radial Forearm; AnteroLateral Thigh flap (ALT); Penile Prostheses; Flap-related Complications; Urologic Complications; and Sexual Health after Surgery.